Foward Reaction

the above relationship says that the rate of formation of enzyme-substrate complex is proportional to the concentration of enzyme and concentration of substrate


this equations says that the rate of formation of enzyme-substrate complex is equal to the concentration of enzyme times the concentration of substrate times the rate constant (k1) of the foward reaction

reverse reaction

this equations says that the rate of formation of substrate is equal to the concentration of enzyme-substrate complex times the rate constant (k-1) of the reverse reaction.

at equilibrium

• the rate of the foward reaction is equal to the rate of the reverse reaction

• at equilibrium, altough the reactions occur, the concentrations of enzyme, substrate and enzyme-substrate complex are not changing.

to put this mathamatically
two ways to write that the rate of the foward reaction is equal to the rate of the reverse reaction are the following.

rearranging the above equations

return of how enzymes do it

return to binding reaction