1. Protein synthesis on the RER

How does the cell decide which proteins will be synthesized on the RER and which will not?

• Proteins that will be synthesized on the RER have a signal sequence

• a protein called the signal sequence recognition protein (SRP) binds to the signal sequence

• the SRP-ribosome complex binds to the rough endoplasmic reticulum

• protein synthesis is completed on the RER

• animation of protein synthesis on RER

2. Protein glycosylation in the RER

Proteins are glycosylated in the lumen of the RER