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Department of Phone: 718-951-5000 ext. 2830
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Our group is interested in fundamental aspects of organic chemistry. Factors that control reactions of oxygen and sulfur species are of interest. We are involved in research of atomic oxygen, singlet molecular oxygen, and other reactive and cytotoxic agents. Some molecules used in our studies (polysulfanes) exhibit cytotoxic properties that must have taken eons to evolve, formed by marine invertebrate to deter predators. Our synthetic chemistry aims to create polysulfanes with increased anti-tumor activity over those found in Nature. Using chemicals synthesized with functionality to initiate cell responses or the modulation of specific cell sensitivity is of interest. Examining toxicity of other reactive intermediates, such as the toxic electrophilic quinones is also of interest. Computations are used to try to deepen our understanding of experiments. We often probe organic mechanisms with computational chemistry; theoretical methods that we use include, ab initio and density functional theory. Currently, our research is supported by the National Institutes of Health. |
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CURRENT GROUP 2008 Dr. |
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[(a) Ph.D. student; (b) MS student; (c) undergraduate student at Brooklyn College] 1. A.
Castillo,(a) J. F. Liebman; A. Greer “Quinones,
Monoradicals and Diradicals From 3- and 4-Mercaptocatechol, and
3,4-Bismercaptocatechol: A Computational Study of a Plausibly Biomimetic
Reaction” J. Sulfur Chem. (submitted). 2. D. Aebisher; N. S. Azar,(b) M.
Zamadar;(a) H. D. Gafney; 3. A. T. Frank;(c)
N. S. Farina;(b) N. Sawwan;(a) O. R. Wauchope;(c)
M. Qi;(b) E. M. Brzostowska;(a) W. Chan;(c)
F. W. Grasso; P. Haberfield; A. Greer “Natural
Macromolecules Have a Possible Limited Structural Diversity” Molecular Diversity 2008 (in press). 4. E.
M. Greer; D. Aebisher; A. Greer; R. Bentley “Computational Studies of
the Tropone Natural Products, Thiotropocin, Tropodithietic acid, and
Troposulfenin. Significance of
Thiocarbonyl-enol Tautomerism” J.
Org. Chem. 2008, 73, 280-283. 5. D. Aebisher; E.
M. Brzostowska;(a) 6. A.
Greer “Organic Chemistry: Molecular Crosstalk” Nature 2007, 447, 273-274. 7. E. M. Brzostowska;(a)
M. Paulynice;(c) R. Bentley, A. Greer “Planar Chirality Due
to a Polysulfur Ring in Natural Pentathiepin Cytotoxins. Implications of Planar Chirality for
Enantiospecific Biosynthesis and Toxicity” Chem. Res. Toxicol. 2007, 20,
1046-1052. 8. D. Aebisher; E.
M. Brzostowska;(a) M. Adaickapillai;(a) A. Greer
“Regioselective (Biomimetic) Synthesis of a Pentasulfane From Ortho-benzoquinone” J. Org. Chem. 2007, 72, 2951-2955.
9. N. Sawwan;(a)
A. Greer “Rather Exotic Types of Cyclic Peroxides: Heteroatom
Dioxiranes” Chemical Reviews 2007, 107, 3247-3285. 10. A. T. Frank;(c)
A. Adenike;(c) D. Aebisher; A. Greer; R. Gao; J. F.
Liebman “Paradigms and Paradoxes:
Energetics of the Oxidative Cleavage of Indigo” Struct. Chem. 2007,
18, 71-74. 11. O. R. Wauchope;(c)
S. Shakya;(b) N. Sawwan;(a) J. F. Liebman; A. Greer
“Photocleavage of Plasmid DNA by Dibenzothiophene S-oxide Under Anaerobic Conditions” J. Sulfur Chem. 2007, 28, 11-17. 12. A. Greer; preface.
“Organic Chemistry of Singlet Oxygen” [In: Tetrahedron 2006; 62, 10603-10776]. 13. A. Greer “Christopher
Foote’s Discovery of the Role of Singlet Oxygen [1O2
(1∆g)] in Photosensitized Oxidation
Reactions” Acc. Chem. Res. 2006, 39, 797-804. 14. A. Greer; O. R. Wauchope;(c)
N. S. Farina;(b) P. Haberfield; J. F. Liebman “Paradigms and Paradoxes: Mechanisms for Possible Enhanced
Biological Activity of Bilaterally Symmetrical Chemicals” Struct. Chem. 2006, 17, 347-350. 15. N. Sawwan;(a) A.
Greer “The Generation of Mono- and
Bis-dioxiranes from 2,3-Butanedione” J. Org. Chem. 2006, 71, 5796-5799. 16. N. Gandra, Aaron T. Frank,(c) O. Le Gendre,(a) N.
Sawwan,(a) D. Aebisher, J. F. Liebman, K. N. Houk, A. Greer,
and R. Gao “Possible
Singlet Oxygen Generation from the Photolysis of Indigo Dyes in Methanol,
DMSO, Water, and Ionic Liquid, 1-Butyl-3-methylimidazolium
tetrafluoroborate” Tetrahedron
2006, 62,
10771-10776. |
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ACADEMIC RECORD Assistant Professor (1999-2003),
Associate Professor (2004-2007), Professor (2008-present) at the |
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