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PATENT and APPLICATIONS: Zhen Huang and Jack
W. Szostak, USA Patent, Title: "A Simple and Efficient Method to Label and Modify
3’-Termini of RNA Using DNA Polymerase and a Synthetic Template with Defined Overhung
Nucleotides", 2001, May, US 6,238,865. Zhen Huang, Title: “Synthesis of Selenium-derivatized Nucleotides and Oligonucleotides”, 2002, USA Patent Application (10/104,995), filed by the CUNY Research Foundation.Zhen Huang, Title: “Synthesis of
Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic
Acids”, 2002, PCT International Application (PCT/US02/8771), filed by the
Research Foundation, CUNY. Zhen Huang, Title: “RNA Selective Detection and Quantitation using RNA Chip and
Plate”, 2003, USA Provisional Patent Application,
filed by the Research Foundation, CUNY.
PUBLICATIONS (selected): Mohammed Alsaidi, Elena Lum, and Zhen Huang*, “PCR-independent Selective Enzymatic Detection of Specific mRNA on microplate”, ChemBioChem, 2004, in press. Yuri Buzin, Nicolas Carrasco, and Zhen
Huang*, “Synthesis of Selenium-Derivatized Cytidine and Oligonucleotides for X-ray
Crystallography Using MAD”, Organic Letter, 2004, 6,
1099-1102. Nicolas Carrasco, Yuri Buzin, Elizabeth Tyson, Elizer Halpert, and Zhen Huang*, “Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple anomalous dispersion”, Nucleic Acids Research, 2004, 32, 1638-1646. Nicolas Carrasco and Zhen Huang*,
“Enzymatic Synthesis of Phosphoroselenoate DNA using Thymidine 5’-(a-P-Seleno)-triphosphate and DNA
Polymerase for X-ray Crystallography using MAD”,
Journal of American Chemical Society, 2004,
126,
448-449. Zhen Huang,* and Mohammed Alsaidi, “Selective Labeling and Detection of Specific mRNA in a Total RNA Sample”, Analytical Biochemistry, 2003, 322, 269-274. Zhen Huang*, and Jack W. Szostak,
“Selective Labeling of RNA in an RNA Mixture”, Analytical Biochemistry, 2003,
315, 129-133. Zhen Huang,* and Jack W. Szostak, “Evolution
of Aptamers with a New Specificity and New Secondary Structures from an ATP Aptamer”, RNA, 2003, 9,
1456-1463. Quan Du, Nicolas Carrasco, Marlanna
Teplova, Christopher J. Wilds, Martin Egli, and Zhen Huang*, “Internal Derivatization
of Oligonucleotides with Selenium for X-ray Crystallography Using MAD”, Journal of American Chemical Society. Zhen Huang and Steven A. Benner,* "Oligodeoxyribonucleotide Analogs with Bridging Dimethylenesulfide, Sulfoxide and Sulfone Groups: Towards a Second Generation Model of Nucleic Acid Structure", Journal of Organic Chemistry, 2002, 67, 3996-4013. Nicolas Carrasco,
Dov Ginsburg, Quan Du, and Zhen Huang*, “Synthesis of Selenium-Derivatized
Nucleosides and Oligonucleotides for X-ray Crystallography”, Nucleosides, Nucleotides, & Nucleic Acids, 2001,
vol. 20, issue 9,
1723-1734. Zhen Huang* and Jun Zhao, “In vitro Selection of Ligand-binding and Catalytic
RNA and DNA”, Frontiers of Biotechnology and
Pharmaceuticals, 2001, Vol. 2, Science Press Ltd., New York, pp9-31. Zhen
Huang, Ming Guo, John Reiner, Kang Zhao, Frontiers
of Biotechnology and Pharmaceuticals, Vol. 2, Science Press Ltd., New York, (June, 2001). Zhen Huang, “Catalytic RNAs and
Ribozyme Gene Therapy”, Frontiers of
Biotechnology and Pharmaceuticals, 2000, Vol. 1, Science Press Ltd.,
New York, pp. 40-58. Steven A. Benner,*
et al, Zhen Huang, et al, "Redesigning
Nucleic Acids", Pure Appl. Chem. 1998,
vol.70, 263-266, (there are 32 authors; besides the first author, names of the others are
largely in alphabet order). Zhen Huang and
Steven A. Benner,* "Regiospecific
Conversion of Primary Hydroxyl Groups to Thioesters and Reduction of Secondary Hydroxyl
Groups", Nucleosides and Nucleotides, 1998,
Vol. 17, 895-900. Zhen Huang and Jack
W. Szostak,* "A Simple Method to Label 3’-end of RNA", Nucleic Acids Research, 1996, Vol.
24, 4360-4361.
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